Better2Know Genetic & DNA

MTHFR (Methylenetetrahydrofolate reductase) Test

This blood test looks for two common variants in the MTHFR gene that affect how your body processes folate and manages homocysteine levels. It suits people investigating unexplained homocysteine results or a relevant family history.

Sample
Blood
Collection
Venous draw at clinic or nurse visit
Results in
5 days
Biomarkers
1
Tests for
  • MTHFR

Test specifications

Provider
Better2Know
Sample type
blood
Collection method
venous draw at clinic or nurse visit
Turnaround time
5 days
Biomarkers tested
1
At-home test
No
Doctor reviewed
No
Gender focus
Both

What's tested

1 biomarker as listed by Better2Know.

  • MTHFR

About this test

MTHFR is a gene involved in processing folate and regulating homocysteine, a compound linked to cardiovascular and pregnancy-related health. This test checks for two common variants, C677T and A1298C, from a blood sample. Carrying one or both variants can affect how your body handles folate, which is why the test is often considered by people with unexplained raised homocysteine, a family history of related conditions, or pregnancy complications. A result showing these variants is not the same as a diagnosis of any condition.

There are no comparable tests listed against this one, so we cannot say how its £247 price or single-marker scope compares with similar genetic panels elsewhere.

The scores show a clearly presented listing, with the description, biomarker and turnaround all stated upfront, but a narrower clinical scope than most genetic and DNA tests we track, since it covers a single gene rather than a wider panel. It also loses marks on results and follow-up because it is not doctor-reviewed as standard.

Who is it for?

This suits people who have been advised to check their MTHFR status because of unexplained homocysteine results, a personal or family history of blood clots or cardiovascular disease, or recurrent pregnancy loss, and who want the result from a single, straightforward blood test. It is not a broad genetic health panel, so if you want wider genetic screening alongside this variant, you would need a separate test. There is no comparison group listed for this test, so we cannot point you to a cheaper or deeper like-for-like alternative.

How it works

A blood sample is taken by venous draw, either at a clinic or during a home nurse visit. The sample is analysed for the C677T and A1298C MTHFR variants. Results are typically available within five days and show whether you carry none, one, or two copies of each variant. The sheet does not state that results are doctor-reviewed as standard.

Pros & cons

Pros

  • Checks both common MTHFR variants, C677T and A1298C, from one sample.
  • Home nurse visit offered as an alternative to a clinic blood draw.
  • Clear listing with description, biomarker and turnaround stated upfront.

Cons

  • Covers a single gene, giving less clinical depth than broader genetic panels.
  • Standard testing does not include a doctor review of results.
  • No comparable test listed, so value for money is hard to benchmark.

Our editorial score

Compare Health Test Score Single-gene MTHFR panel, no doctor review included
Editorial confidence: 9.0/10

This test checks for the C677T and A1298C MTHFR variants from a single blood sample, with results in five days. At £247 there is no comparable test in our data to benchmark it against, and results are not doctor-reviewed as standard.

Score breakdown

  • Clarity and documentation 9.0/10

    The listing publishes a detailed description, the full biomarker list, a stated turnaround, clear collection options, the sample type; it does not state what the report looks like.

  • Clinical depth 4.7/10

    1 biomarkers, placing it in the 3rd percentile of genetic dna tests we track.

  • Collection convenience 6.0/10

    Requires a venous draw at a clinic; a home nurse visit is offered; results in around 5 days, well ahead of the genetic dna norm of 14.

  • Results and follow-up 3.0/10

    Results are not doctor-reviewed and no consultation is included; the provider does not describe the report format.

  • Trust signals 6.5/10

    Trustpilot 4.2 from 775 reviews; CQC registered; trading 18+ years.

  • Value for money 6.0/10

    £247.00; no comparable tests to benchmark against yet.

Calculated 13 September 2026 from the facts we hold about this test and provider, using our published scoring formula. Scores are not hand-edited.

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