Medichecks Inflammation & autoimmunity

Extractable Nuclear Antibodies (ENA) Blood Test

This blood test checks for eight autoantibodies commonly associated with autoimmune conditions such as lupus or Sjögren's syndrome. It suits people with unexplained symptoms like joint pain, fatigue or dry eyes who want to investigate a possible autoimmune cause.

  • Doctor reviewed
Sample
Blood
Collection
In-store clinic or home nurse visit or venous draw at clinic
Results in
5 days
Biomarkers
8
Doctor reviewed
Yes
Tests for
  • Anti CEN-P Antibodies
  • Anti Jo1 antibodies
  • Anti La SS - B Antibodies
  • Anti Ro SS-A Antibodies
  • Anti Scl 70 Antibodies
  • Anti Sm Antibodies
  • Anti U1RNP Antibodies
  • Extractable nuclear antigen

Test specifications

Provider
Medichecks
Sample type
blood
Collection method
in-store clinic or home nurse visit or venous draw at clinic
Turnaround time
5 days
Biomarkers tested
8
At-home test
No
Doctor reviewed
Yes
Gender focus
Both

What's tested

8 biomarkers as listed by Medichecks.

Autoimmunity

  • Anti CEN-P Antibodies
  • Anti Jo1 antibodies
  • Anti La SS - B Antibodies
  • Anti Ro SS-A Antibodies
  • Anti Scl 70 Antibodies
  • Anti Sm Antibodies
  • Anti U1RNP Antibodies
  • Extractable nuclear antigen

About this test

This test measures eight extractable nuclear antibodies, including anti-Ro, anti-La, anti-Sm, anti-Jo1, anti-Scl-70, anti-CENP and anti-U1RNP, alongside a general extractable nuclear antigen marker. These autoantibodies are commonly raised in autoimmune conditions such as lupus and Sjögren's syndrome, where the immune system mistakenly targets the body's own tissues, so the panel is aimed at people with unexplained symptoms like joint pain, fatigue or dry eyes who want to investigate a possible underlying cause.

Medichecks does not list a named comparison group for this test, but against the wider set of inflammation tests we track, its eight markers put it right at the top of the range for this type of test, while its £89 price sits well below the typical cost of similarly sized inflammation tests.

That combination of a high marker count and a below-average price drives very strong clinical depth and value-for-money scores. It also scores well for results and follow-up, since a doctor reviews every result, and for clarity and documentation, because the listing sets out the biomarkers, sample type and collection options clearly. It scores more moderately on collection convenience because it requires a venous draw at a clinic, though a home nurse visit is offered.

Who is it for?

This suits you if you have unexplained symptoms such as persistent joint pain, fatigue or dry eyes and want to check for autoantibodies linked to autoimmune conditions like lupus or Sjögren's syndrome, ideally alongside seeing a GP about those symptoms. Medichecks does not list a peer test in our data for this specific antibody panel, so we cannot confirm whether a cheaper or deeper alternative exists elsewhere, but based on the data we hold, its combination of a wide marker count and below-average price makes it a reasonably strong option for this type of screen. It is not a diagnostic test, so a raised result needs following up with a doctor rather than being treated as a conclusion in itself.

How it works

You can have this done at an in-store clinic, through a home nurse visit, or with a venous blood draw at a clinic; Medichecks does not offer an at-home finger-prick option for this test. Results are typically ready within 5 days, and every result is reviewed by a doctor before you receive it.

Pros & cons

Pros

  • Covers eight autoantibody markers, among the deepest inflammation-category tests we track.
  • At £89, well under half the £159 median for similarly sized inflammation tests we track.
  • Every result is reviewed by a doctor.
  • Clear listing of sample type, collection options and turnaround.

Cons

  • No finger-prick option; results depend on a venous sample taken at a clinic or by a nurse visit.
  • Cannot diagnose lupus, Sjögren's syndrome or any other condition on its own.
  • No named peer test in our data, so we cannot confirm this is the best-value option available.

Our editorial score

Compare Health Test Score Eight-marker autoimmunity screen at low cost
Editorial confidence: 10.0/10

Eight extractable nuclear antibodies are screened here, markers linked to autoimmune conditions including lupus and Sjögren's syndrome. At £89 it costs well under half the £159 median for similarly sized inflammation tests we track, while its eight markers place it right at the top for depth among tests of this kind. It cannot diagnose a specific condition on its own, only flag markers worth discussing with a doctor.

Score breakdown

  • Clarity and documentation 8.0/10

    The listing publishes a short description, the full biomarker list, a stated turnaround, clear collection options, the sample type; it does not state what the report looks like.

  • Clinical depth 10.0/10

    8 biomarkers, placing it in the 97th percentile of inflammation tests we track.

  • Collection convenience 8.0/10

    A blood sample taken at home by a visiting nurse or phlebotomist; with a venous or clinic option as well; a home nurse visit is offered; results in around 5 days, slower than similar tests.

  • Results and follow-up 7.0/10

    Results are reviewed by a doctor; the provider does not describe the report format.

  • Trust signals 9.5/10

    Trustpilot 4.5 from 2,477 reviews; accredited lab (UKAS ISO 15189 partner labs); doctor review as standard; trading 25+ years.

  • Value for money 8.7/10

    £89.00 against a median of £159.00 for the 5 similarly sized inflammation tests we track (-44%).

Calculated 13 September 2026 from the facts we hold about this test and provider, using our published scoring formula. Scores are not hand-edited.

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