Vital Duo

A bundle combining Stride's 110-gene DNA & Methylation test with its 70+ marker Optimal Bloods test, giving DNA and blood results together. It covers more markers in total than any other test in its comparison group.

  • At-home test
Sample
Mixed
Collection
At-home cheek swab, posted to the lab + at-home venous draw by a visiting phlebotomist
Results in
7–10 days
Biomarkers
180
Doctor reviewed
No
Tests for
  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • +48 more

Test specifications

Provider
Stride
Sample type
mixed
Collection method
at-home cheek swab, posted to the lab + at-home venous draw by a visiting phlebotomist
Turnaround time
7–10 days
Biomarkers tested
180
At-home test
Yes
Doctor reviewed
No
Gender focus
Both

What's tested

60 biomarkers as listed by Stride, of 180 in total.

Methylation

  • ADNOS3
  • BHMT
  • CBS (C699T)
  • COMT
  • DHFR
  • FUT2
  • GSS
  • MAOA
  • MAOB
  • MTHFD1
  • MTHFR (A1298C)
  • MTHFR (C677T)
  • MTR
  • MTRR
  • PEMT
  • SOD2ORA2A
  • TCN2
  • VDR

Nutrition

  • ACE
  • ADH1C
  • ADRB2
  • AGT
  • ALDOB
  • APOA2
  • APOA5
  • APOC3
  • APOE
  • BCMO1
  • BCO1
  • CAT
  • CBS
  • CETP
  • CLOCK
  • CYP1A2
  • CYP4F2
  • EPHX1
  • FABP2
  • FTO
  • GPX1
  • GSTT1
  • HFE
  • HLA DQ2/DQ8
  • IL6
  • INSIG
  • LCT/MCM6
  • LEPR
  • LIPC
  • LPL
  • MC4R
  • NBPF3
  • PLIN
  • PPARG
  • SLC23A1
  • SOD2
  • TCF7L2
  • TF
  • TFR2
  • TMPRSS6
  • TNF
  • ZPR1

About this test

This is a bundle of two Stride tests: the 110-gene Optimal DNA & Methylation panel and the Optimal Bloods test, which covers more than 70 blood biomarkers spanning metabolic health, hormones, inflammation and cardiovascular risk. You provide two samples, an at-home cheek swab and an at-home venous blood draw by a visiting phlebotomist.

Combining the two brings the total to 180 markers, the highest count among the ten tests in the general health check comparison group, ahead of Randox Health's RanChip Insight 360 (160 markers, £495) and its Everyman/Everywoman Complete (95 markers, £416). That depth comes at a price of £460.85, which is 13% above the £407.50 group median, so it scores well on clinical depth but only around the middle on value for money.

It scores well for clarity and documentation, since Stride sets out both components and their sample types clearly. Collection convenience is middling because it combines two sample types and the DNA portion adds a few days to the fastest possible blood-only turnaround. Results and follow-up sit in the middle, reflecting the included consultation against results that are not doctor-reviewed.

Who is it for?

This suits people who want the broadest combined marker count of any test in this comparison group and are willing to provide two samples and pay above the group median price for it. It brings DNA and current blood biomarkers together rather than requiring two separate purchases.

If you only want the blood panel, Stride's standalone Optimal Bloods test covers 70+ markers for £399, £61.85 less. If marker count matters more than combining DNA, Randox Health's RanChip Insight 360 covers 160 markers for £495.

How it works

You provide two samples: an at-home cheek swab for the DNA test and an at-home venous blood draw carried out by a visiting phlebotomist. Stride states DNA results are returned in around 10 working days and blood results in around 7 working days. A one-to-one consultation is included, though results are not reviewed by a doctor.

Pros & cons

Pros

  • Covers 180 markers in total, the highest count in its comparison group.
  • Combines DNA and current blood biomarkers in a single purchase.
  • At-home collection throughout: cheek swab plus a visiting phlebotomist for blood.
  • Includes a one-to-one consultation with a Stride expert.

Cons

  • Priced 13% above the group median for comparable general health checks.
  • £61.85 more than Stride's standalone Optimal Bloods test.
  • Results are not reviewed by a doctor.
  • Two separate samples to provide rather than one.

Our editorial score

Compare Health Test Score Highest marker count in the general health check group
Editorial confidence: 10.0/10

Vital Duo combines Stride's 110-gene Optimal DNA & Methylation test with its 70+ marker Optimal Bloods test for £460.85, covering 180 markers in total, more than any other test in its comparison group. That breadth comes at a price 13% above the £407.50 group median, and results are not reviewed by a doctor.

Score breakdown

  • Clarity and documentation 9.0/10

    The listing publishes a detailed description, the full biomarker list, a stated turnaround, clear collection options, the sample type; it does not state what the report looks like.

  • Clinical depth 10.0/10

    180 biomarkers against a median of 82.5 across the 10 tests in its comparison group.

  • Collection convenience 7.0/10

    A blood sample taken at home by a visiting nurse or phlebotomist; with a venous or clinic option as well; results in around 10 days, slower than similar tests.

  • Results and follow-up 6.0/10

    A one-to-one consultation is included in the price, though results are not doctor-reviewed; the provider does not describe the report format.

  • Trust signals 7.5/10

    Trustpilot 4.7 from 148 reviews; accredited lab (UKAS accredited labs); trading 22+ years.

  • Value for money 5.6/10

    £460.85 against a comparison-group median of £407.50 (+13%).

Calculated 13 September 2026 from the facts we hold about this test and provider, using our published scoring formula. Scores are not hand-edited.

Compare with similar tests

This test belongs to our Ultimate health check (over 50 markers) comparison group. See how it stacks up against equivalent tests from other providers.

View all →

Optimal Health Blood Test

Cheapest in its group, though fewer markers than most peers

A 59-marker blood panel covering cholesterol, thyroid, hormone, iron, kidney, liver and blood-count markers. Suited to women who want a broad overview of long-term health rather than a single-issue check.

8.1 / 10

Optimal Bloods

Priced within 2% of the general health check group median

An at-home blood test covering 70+ biomarkers spanning cardiovascular health, hormones, nutrient status and organ function, taken via a visiting phlebotomist. Suits people wanting a broad general health check without a clinic visit.

  • At-home test
7.4 / 10