A bundle combining Stride's 110-gene Optimal DNA & Methylation test with three months' supply of its methylated B-vitamin supplement. Suits people who want the deepest methylation panel plus an ongoing supplement in one purchase.
60 biomarkers as listed by Stride, of 110 in total.
This is a bundle: the same 110-gene panel as Stride's standalone Optimal DNA & Methylation test, covering methylation cycles (including MTHFR and COMT) plus nutrition, fitness, sleep, stress and skin genes, combined with three months' supply of MS-01, a daily supplement containing methylated forms of B6, folate and B12 alongside TMG and vitamin C. The sample is an at-home cheek swab.
Within Stride's own DNA and methylation range, this is the most expensive option: the Core test costs £109.85 for 19 genes, the Advanced test £174.85 for 52 genes, and the standalone Optimal test £207.35 for the same 110 genes without the supplement. Against the wider comparison group, its 110 genes sit well above the group median of 81, but at £278.85 it is 46% above the £191.10 group median price, which drags down its value for money score even though clinical depth and documentation both score highly.
It scores near the top for clinical depth and for clarity and documentation, since Stride publishes the full gene list, sample type, turnaround and a description of the report. Collection convenience is strong thanks to the simple swab and roughly 10-day turnaround. Results and follow-up score reasonably, reflecting the included consultation and a described genetic report format, though results are still not reviewed by a doctor.
This suits people who have decided they want the full 110-gene panel and also want an ongoing methylated B-vitamin supplement, and are willing to pay a premium for the convenience of buying both together. It is not the cheapest way to get the 110-gene analysis on its own.
If you want the same gene panel without the supplement, Stride's standalone Optimal DNA & Methylation Test covers it for £207.35, £71.50 less. If budget matters more than gene count, the Core test covers the core methylation cycles for £109.85.
You collect a sample yourself using an at-home cheek swab and post it to the lab; Stride states results are returned in around 10 working days as a genetic report. Alongside the DNA test, you receive three months' supply of MS-01, a daily supplement with methylated B6, B9 and B12, TMG and vitamin C, taken as one capsule a day. A one-to-one consultation is included, though results are not reviewed by a doctor.
The Methylation Stack bundles Stride's 110-gene Optimal DNA & Methylation test with three months of MS-01, a methylated B-vitamin supplement, for £278.85. That makes it the most expensive of Stride's four DNA and methylation panels, 46% above the £191.10 group median, though it does match the Optimal test's gene count. The main trade-off is price against Stride's own cheaper tiers, since results are not doctor-reviewed.
The listing publishes a detailed description, the full biomarker list, a stated turnaround, clear collection options, the sample type, what the report contains.
110 biomarkers against a median of 81 across the 4 tests in its comparison group.
A swab sample you take at home, no needle; results in around 10 days, in line with or faster than similar tests.
A one-to-one consultation is included in the price, though results are not doctor-reviewed; genetic-report report.
Trustpilot 4.7 from 148 reviews; accredited lab (UKAS accredited labs); trading 22+ years.
£278.85 against a comparison-group median of £191.10 (+46%).
Calculated 13 September 2026 from the facts we hold about this test and provider, using our published scoring formula. Scores are not hand-edited.
This test belongs to our DNA and methylation test comparison group. See how it stacks up against equivalent tests from other providers.
Ties for the deepest gene count among Stride's DNA panels
A cheek-swab DNA test covering 110 genes across methylation, nutrition, fitness, sleep, stress and skin. Suits people wanting Stride's fullest standalone DNA panel without the supplement bundle.
Middle of Stride's three DNA tiers on price and gene count
A cheek-swab DNA test analysing 52 genes across methylation and nutrient metabolism, showing how your body processes folate, B vitamins and dietary fat. Suited to people wanting more than a basic methylation panel without paying for the full 110-gene version.
Cheapest of Stride's DNA and methylation panels
A cheek-swab DNA test covering 19 genes across the five core methylation cycles, showing how efficiently your body processes folate and other B vitamins. Suits people wanting an entry-level look at methylation genetics.
Ties for the deepest gene count among Stride's DNA panels
A cheek-swab DNA test covering 110 genes across methylation, nutrition, fitness, sleep, stress and skin. Suits people wanting Stride's fullest standalone DNA panel without the supplement bundle.
Middle of Stride's three DNA tiers on price and gene count
A cheek-swab DNA test analysing 52 genes across methylation and nutrient metabolism, showing how your body processes folate, B vitamins and dietary fat. Suited to people wanting more than a basic methylation panel without paying for the full 110-gene version.
Cheapest of Stride's DNA and methylation panels
A cheek-swab DNA test covering 19 genes across the five core methylation cycles, showing how efficiently your body processes folate and other B vitamins. Suits people wanting an entry-level look at methylation genetics.
