A cheek-swab DNA test analysing 52 genes across methylation and nutrient metabolism, showing how your body processes folate, B vitamins and dietary fat. Suited to people wanting more than a basic methylation panel without paying for the full 110-gene version.
60 biomarkers as listed by Stride.
This test analyses 52 genes split between core methylation pathways (including MTHFR, COMT and MTR) and diet-related genes (including APOE, FTO and LCT/MCM6). Methylation genes are commonly used to assess how efficiently your body processes folate and other B vitamins, while the nutrition genes relate to how you metabolise fats, carbohydrates and other nutrients. The sample is a cheek swab you take at home.
Within Stride's own DNA and methylation range, this Advanced tier sits in the middle: it covers more genes than the Core test (19 genes, £109.85) but fewer than the Optimal test and Methylation Stack (110 genes each, £207.35 and £278.85). Against the wider comparison group of DNA and methylation tests we track, its 52 genes fall below the group median of 81, which is reflected in a below-average clinical depth score. On price, at £174.85 it comes in below the group median of £191.10.
It scores well for clarity and documentation because the listing sets out a full biomarker list, sample type, collection method and turnaround, and well for collection convenience because the swab is simple to use at home with results due in around 10 days. It scores lower for results and follow-up: a one-to-one consultation is included in the price, but results are not reviewed by a doctor and Stride does not describe what the report itself looks like.
This suits people who already know they want a broader read on methylation and diet-related genetics than a basic panel gives, but who do not need the full 110-gene Optimal test or Methylation Stack. It's a reasonable middle step if budget is a factor but you still want the nutrition genes alongside the core methylation cycles.
If cost is the main concern, Stride's own Core DNA & Methylation Test covers the same methylation cycles for £109.85, without the nutrition genes. If you want the fullest picture, the Optimal DNA & Methylation Test adds fitness, sleep, stress and skin genes for £207.35, or the Methylation Stack bundles the same 110 genes with a supplement for £278.85.
You collect a sample yourself with an at-home cheek swab and post it to the lab; no blood or finger-prick is involved. Stride states results are returned in around 10 working days. A one-to-one consultation is included in the price, though the sheet does not describe how results are presented or reviewed, and results are not reviewed by a doctor.
The Advanced DNA & Methylation Test reads 52 genes covering methylation and nutrient metabolism from a cheek swab, with results in 10 working days. At £174.85 it sits between Stride's own Core test (19 genes, £109.85) and Optimal test (110 genes, £207.35), so it suits people who want more than the basic panel but do not need the full gene set. The biggest caveat is that results are not reviewed by a doctor.
The listing publishes a detailed description, the full biomarker list, a stated turnaround, clear collection options, the sample type; it does not state what the report looks like.
52 biomarkers against a median of 81 across the 4 tests in its comparison group.
A swab sample you take at home, no needle; results in around 10 days, in line with or faster than similar tests.
A one-to-one consultation is included in the price, though results are not doctor-reviewed; the provider does not describe the report format.
Trustpilot 4.7 from 148 reviews; accredited lab (UKAS accredited labs); trading 22+ years.
£174.85 against a comparison-group median of £191.10 (-9%).
Calculated 13 September 2026 from the facts we hold about this test and provider, using our published scoring formula. Scores are not hand-edited.
This test belongs to our DNA and methylation test comparison group. See how it stacks up against equivalent tests from other providers.
Ties for the deepest gene count among Stride's DNA panels
A cheek-swab DNA test covering 110 genes across methylation, nutrition, fitness, sleep, stress and skin. Suits people wanting Stride's fullest standalone DNA panel without the supplement bundle.
Priciest of Stride's DNA and methylation panels
A bundle combining Stride's 110-gene Optimal DNA & Methylation test with three months' supply of its methylated B-vitamin supplement. Suits people who want the deepest methylation panel plus an ongoing supplement in one purchase.
Cheapest of Stride's DNA and methylation panels
A cheek-swab DNA test covering 19 genes across the five core methylation cycles, showing how efficiently your body processes folate and other B vitamins. Suits people wanting an entry-level look at methylation genetics.
Ties for the deepest gene count among Stride's DNA panels
A cheek-swab DNA test covering 110 genes across methylation, nutrition, fitness, sleep, stress and skin. Suits people wanting Stride's fullest standalone DNA panel without the supplement bundle.
Priciest of Stride's DNA and methylation panels
A bundle combining Stride's 110-gene Optimal DNA & Methylation test with three months' supply of its methylated B-vitamin supplement. Suits people who want the deepest methylation panel plus an ongoing supplement in one purchase.
Cheapest of Stride's DNA and methylation panels
A cheek-swab DNA test covering 19 genes across the five core methylation cycles, showing how efficiently your body processes folate and other B vitamins. Suits people wanting an entry-level look at methylation genetics.
